The Four mRNA Bases Have Quite Different (Un)folding Free Energies, Applications to RNA Splicing and Translation Initiation with BindOligoNet

Autor:	Julian M, Hess, William K, Jannen, Daniel P, Aalberts
Rok vydání:	2022
Předmět:	Binding Sites Nucleotides Structural Biology RNA Splicing RNA Small Nuclear Spliceosomes Nucleic Acid Conformation Thermodynamics RNA Messenger Peptide Chain Initiation Translational Molecular Biology Algorithms
Zdroj:	Journal of Molecular Biology. 434:167578
ISSN:	0022-2836
DOI:	10.1016/j.jmb.2022.167578
Popis:	Expression of mRNA is often regulated by the binding of a small RNA (miRNA, snoRNA, siRNA). While the pairing contribution to the net free energy is well parameterized and can be computed in O(N) time, the cost of removing pre-existing mRNA secondary structure has not received sufficient attention. Conventional methods for computing the unfolding free energy of a target mRNA are costly, scaling like the cube of the number of target bases O(N
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd1cb3b99c4af8334f5768907dad48d https://doi.org/10.1016/j.jmb.2022.167578 Zobrazit plný text záznamu Full Text from ScienceDirect