The Use of Cyclosporine, FK506, and SDZ NIM811 to Prevent CD25 Quiescent Peripheral Blood Mononuclear Cells from Producing Human Immunodeficiency Virus
| Autor: | Chin Sheng Chou, Brigitte Rosenwirth, Ellen S. Vitetta, Octavio Ramilo, Gregory Van Dyke, Jozef Borvak |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_treatment
HIV Receptors Interleukin-2 Biological activity Biology Antiviral Agents Peripheral blood mononuclear cell Virology Coculture Techniques Tacrolimus In vitro Virus Infectious Diseases Immunosuppressive drug Immunotoxin Cell culture Cyclosporine Leukocytes Mononuclear medicine Humans Immunology and Allergy IL-2 receptor Cell Division Immunosuppressive Agents |
| Zdroj: | Journal of Infectious Diseases. 174:850-853 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/174.4.850 |
| Popis: | It has been shown that the combined use of two pharmacologic agents can inhibit human immuno deficiency virus (HIV) production by peripheral blood mononuclear cells in vitro. One, an anti CD25 immunotoxin (IT), kills activated T cellsthat produce virus; the other, the immunosuppressive drug cyclosporine, prevents the quiescent cells, which harbor HIV, from becoming activated. The present study compares the antiviral activities of two agents, SDZ NIM811 and FK506, to that of cyclosporine. In combination with the anti-CD25 IT, these drugs significantly suppressed virus production. In the absence of prior addition of the IT, the ability of the drugs to inhibit virus production was much lower, suggesting that they work effectively in latently infected cells. In the case of SDZ NIM811, the inhibition of virus production was accompanied by a modest inhibition of cell proliferation. In contrast, FK506 exerted strong anti proliferative activity. Cyclosporine was both moderately antiproliferative and a potent antiviral agent. |
| Databáze: | OpenAIRE |
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