Early endoscopic treatment of acute inflammatory airway lesions improves the outcome of postintubation airway stenosis
Autor: | Arvind Singh, David J. Howard, Catriona Ferguson, S. A. Reza Nouraei, Anil Patel, Guri Sandhu |
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Rok vydání: | 2006 |
Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Scars Injections Intralesional Catheterization Lesion medicine Intubation Intratracheal Intubation Humans Inflammation medicine.diagnostic_test Laryngoscopy business.industry Middle Aged medicine.disease Tracheal Stenosis Surgery Endoscopy Airway Obstruction Trachea Stenosis Otorhinolaryngology Anesthesia Acute Disease Corticosteroid Female Steroids Laser Therapy medicine.symptom Airway business |
Zdroj: | The Laryngoscope. 116(8) |
ISSN: | 0023-852X |
Popis: | Objectives/Hypothesis: The objective of this study was to compare the results of treating acute postintubation stenotic airway lesions with the results of treating mature lesions and to assess whether early intervention improves the outcome. Methods: Patients without previous surgery, treated for postintubation airway stenosis, were reviewed. Those with airway lesions presenting within weeks of intubation (n = 11) were treated with intralesional steroids, laser reduction, and balloon dilatation. Patients with mature airway lesions (n = 20) were initially treated with laser, balloon dilatation, and topical mitomycin C. Preoperative patient and lesion characteristics, details of the treatment, and intervention-free intervals were recorded. Data were compared with unpaired Student t test or χ2 test as appropriate, and intervention-free intervals were compared with log-rank statistics. Cox regression was used to identify independent predictors of intervention-free interval. Results: There were 18 males and 13 females. The average age at presentation was 47 ± 2.7 years. The two groups were statistically comparable for demographic and lesion characteristics. Patients treated for acute injury required significantly fewer interventions (P < .03), the majority being treated with a single treatment. They had a significantly longer intervention-free interval (P < .02; log-rank analysis) and did not require external laryngotracheal reconstruction (P < .001) compared with patients treated for mature fibrotic scars leading to airway stenosis. Conclusions: Early treatment of acute fibroinflammatory airway lesions has the potential to favorably modify the natural history of postintubation tracheal injury, raising the tantalizing possibility of an early cure. These findings have significant implications for early identification, referral, and treatment of postintubation tracheal stenosis and need to be confirmed with further studies. |
Databáze: | OpenAIRE |
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