Type 1 diabetes mellitus, coeliac disease, and lymphoma: a report of four cases
| Autor: | J F Loane, Domhnall J O'Halloran, Terence M. O'Connor, Cornelius C. Cronin, N M O'Meara, Fergus Shanahan, R G Firth |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphoma B-Cell Lymphoma Diabetic ketoacidosis Endocrinology Diabetes and Metabolism Disease Lymphoma T-Cell Malignancy Gastroenterology Coeliac disease Diabetic Ketoacidosis Endocrinology immune system diseases hemic and lymphatic diseases Internal medicine Internal Medicine medicine Humans T-cell lymphoma B-cell lymphoma Aged Type 1 diabetes business.industry nutritional and metabolic diseases Middle Aged medicine.disease Hodgkin Disease digestive system diseases Celiac Disease Diabetes Mellitus Type 1 Immunology Female business |
| Zdroj: | Diabetic Medicine. 16:614-617 |
| ISSN: | 1464-5491 0742-3071 |
| Popis: | Summary Introduction Patients with Type 1 diabetes mellitus have a high prevalence of coeliac disease, symptoms of which are often mild, atypical, or absent. Untreated coeliac disease is associated with an increased risk of malignancy, particularly of lymphoma. We describe four patients with Type 1 diabetes mellitus and coeliac disease who developed lymphoma. Case reports Two patients were male and two female. In three patients, coeliac disease and lymphoma were diagnosed simultaneously. Enteropathy-associated T cell lymphoma occurred in two patients, Hodgkin’s disease in one, and B cell lymphoma in one. Response to treatment was in general poor, and three patients died soon after the diagnosis of lymphoma was made. Conclusion As the relative risk of lymphoma is reduced by a gluten-free diet, a high index of suspicion for coeliac disease should exist in all Type 1 diabetic patients with unexplained constitutional or gastro- intestinal symptoms. Keywords coeliac disease, lymphoma, Type 1 diabetes mellitus |
| Databáze: | OpenAIRE |
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