Impact of the eosinophil variability on severe exacerbations in an asthmatic population
| Autor: | B. Andrade, Aina Millán Pons, Job F M van Boven, Miguel Román Rodríguez, Josep Muncunill Farreny, Núria Toledo Pons, Borja García Cosío Piqueras, Janwillem W. H. Kocks |
|---|---|
| Přispěvatelé: | Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Receiver operating characteristic business.industry Coefficient of variation Population Airway management respiratory system Eosinophil medicine.disease medicine.anatomical_structure Interquartile range Internal medicine Cohort Asthma - mechanism medicine Eosinophilia medicine.symptom education business Biomarkers Asthma |
| Zdroj: | European Respiratory Journal, 56. EUROPEAN RESPIRATORY SOC JOURNALS LTD |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | Eosinophilic inflammation is an important treatable trait in airway diseases. The characterization of eosinophilia, its comparison with an unselected population and the implication of eosinophil variability have not been studied yet.Our objectives were to compare the distribution of blood eosinophils between an asthma population and a general population and to find the best variable among eosinophil count and dispersion variables that classifies patients at risk of hospitalization. Patients from the MAJORICA cohort were studied. Asthma patients≥18 year-old with at least one stable blood eosinophil count were studied. Control individuals with blood routine tests were selected. Eosinophil data were analysed as the mean, median and maximum values. Standard deviation, coefficient of variation (CV), and interquartile range were used to study dispersion. The association between eosinophil variables and the risk of hospitalization was studied using correlations and ROC curves. 10,059 patients and 8,623 controls were included with 35,703 and 8,822 eosinophil determinations. Asthma patients had higher levels of eosinophils and greater dispersion compared to controls (217 (115-357) vs 190 (120-290) cells/μL p Asthma patients present higher eosinopihl values and variability compared to an unselected population. Eosinophil variability in an asthma population has a better predictive capacity for hospitalization than absolute values. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|