High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch
Autor: | Huibert D. Mansvelder, Christiaan P. J. de Kock, Rebecca A. Mease, Jean L Pie, Marcel Oberlaender, Anton W. Pieneman, Bert Sakmann, JM Guest, Arco Bast |
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Přispěvatelé: | Integrative Neurophysiology, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience - Cellular & Molecular Mechanisms |
Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine QH301-705.5 Thalamus Action Potentials Medicine (miscellaneous) Biology Somatosensory system Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Bursting 0302 clinical medicine Cortex (anatomy) medicine Animals Biology (General) Rats Wistar Prefrontal cortex Neurons integumentary system Whisking in animals Somatosensory Cortex Rats Electrophysiology 030104 developmental biology medicine.anatomical_structure Touch Vibrissae Sensory processing Whisker system Brainstem General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Communications biology, 4(1):709. Nature Research Communications Biology de Kock, C P J, Pie, J, Pieneman, A W, Mease, R A, Bast, A, Guest, J M, Oberlaender, M, Mansvelder, H D & Sakmann, B 2021, ' High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch ', Communications biology, vol. 4, no. 1, 709 . https://doi.org/10.1038/s42003-021-02241-8 Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
ISSN: | 2399-3642 |
Popis: | Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identified excitatory cell-types in primary somatosensory cortex in naive, untrained rats. We find major differences across layers and cell-types. The temporal structure of spontaneous spiking contains high-frequency bursts (≥100 Hz) in all morphological cell-types but a significant increase upon whisker touch is restricted to layer L5 thick-tufted pyramids (L5tts) and thus provides a distinct neurophysiological signature. We find that whisker touch can also be decoded from L5tt bursting, but not from other cell-types. We observed high-frequency bursts in L5tts projecting to different subcortical regions, including thalamus, midbrain and brainstem. We conclude that bursts in L5tts allow accurate coding and decoding of exploratory whisker touch. In order to investigate the information encoded by spiking activity in different neuronal cell types in the primary somatosensory cortex, de Kock et al performed electrophysiological recordings in untrained rats. They demonstrated that an increase in high-frequency burst spiking in thick tufted pyramids in layer 5 of the cortex allow accurate encoding of exploratory whisker touch. |
Databáze: | OpenAIRE |
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