Assessment of Risks Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Experimental Human Infection Studies
| Autor: | Ingrid M C Kamerling, Meta Roestenberg, Frits R. Rosendaal, Vincent P. Kuiper, Leonardus Gerardus Visser |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Isolation (health care) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Secondary infection 030204 cardiovascular system & hematology medicine.disease_cause Viewpoints Article Disease Outbreaks 03 medical and health sciences 0302 clinical medicine Medicine Humans 030212 general & internal medicine Intensive care medicine Risk management Coronavirus human challenge model business.industry SARS-CoV-2 Outbreak COVID-19 risk assessment Residual risk Infectious Diseases AcademicSubjects/MED00290 business Risk assessment controlled human infection model |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America Clinical Infectious Diseases Clinical Infectious Diseases, 73(5), E1228-E1234. OXFORD UNIV PRESS INC |
| ISSN: | 1537-6591 |
| Popis: | Controlled human infection (CHI) models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been proposed as a tool to accelerate the development of vaccines and drugs. Such models carry inherent risks. Participants may develop severe disease or complications after deliberate infection. Prolonged isolation may negatively impact their well-being. Through secondary infection of study personnel or participant household contacts, the experimental virus strain may cause a community outbreak. We identified risks associated with such a SARS-CoV-2 CHI model and assessed their likelihood and impact and propose strategies that mitigate these risks. In this report, we show that risks can be minimized with proper risk mitigation strategies; the residual risk, however, should be weighed carefully against the scientific and social values of such a CHI model. |
| Databáze: | OpenAIRE |
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