Usefulness of left ventricular diastolic function assessed by magnetic resonance imaging over invasive coronary flow reserve measurement for detecting cardiac allograft vasculopathy in heart transplant recipients
| Autor: | Yutaka Kubo, Shinichi Nunoda, Masami Hirata, Haruhiko Machida, Shinya Kojima, Kiyotaka Okajima, Eiko Ueno, Kazunobu Shitakura, Kuniaki Otsuka |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cardiac function curve medicine.medical_specialty Adolescent medicine.medical_treatment Diastole Magnetic Resonance Imaging Cine Coronary Artery Disease Asymptomatic Ventricular Function Left Coronary artery disease Young Adult Coronary circulation Predictive Value of Tests Coronary Circulation Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Child Ultrasonography Interventional Retrospective Studies Heart transplantation Chi-Square Distribution business.industry Microcirculation Age Factors Coronary flow reserve Middle Aged medicine.disease Transplantation medicine.anatomical_structure ROC Curve Linear Models cardiovascular system Cardiology Heart Transplantation Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | The International Journal of Cardiovascular Imaging. 29:151-157 |
| ISSN: | 1573-0743 1569-5794 |
| DOI: | 10.1007/s10554-012-0070-0 |
| Popis: | Heart transplant recipients undergo annual screening of early-stage cardiac allograft vasculopathy (CAV) by invasive coronary flow reserve (CFR) measurement. We compared the sensitivity for CAV detection between the CFR measurement and noninvasive magnetic resonance (MR) assessment of left ventricular (LV) diastolic function. In 46 asymptomatic recipients (29 men, aged 35.2 ± 16.1 years) 7.9 ± 4.3 years after transplantation, we measured LV peak filling rate (PFR) using cine MR and CFR in the left anterior descending artery by Doppler guidewire; classified recipients of class 0-2 as negative for CAV and class 3-4, positive, according to Stanford classification assessed by IVUS; compared those values between the 2 groups; and calculated receiver operating characteristic curve in the relationship between PFR value and CAV. We classified 20 recipients (43%) positive and 26 (57%) negative for CAV. Although there was no significant difference in CFR value, the PFR value was significantly lower in the positive (3.54 ± 0.84 EDV/s) than in negative group (4.39 ± 0.85 EDV/s, P = 0.002). Area under the curve was 0.78, and the sensitivity was 78% and specificity, 61%, when PFR cut-off value was 4.20. MR PFR measurement provides noninvasive prediction of CAV, preceding impaired CFR in asymptomatic recipients. |
| Databáze: | OpenAIRE |
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