Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation
Autor: | Xuan Zhu, Lantian Zhou, Yue Zhang, Yongze Ge, Jianyi Pan |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Microbiology (medical)
Cell signaling lcsh:QR1-502 Review medicine.disease_cause Microbiology lcsh:Microbiology 03 medical and health sciences Extracellular polymeric substance medicine bacteria 030304 developmental biology 0303 health sciences biology 030306 microbiology Chemistry Biofilm quorum sensing Pathogenic bacteria biochemical phenomena metabolism and nutrition biology.organism_classification Quorum sensing Quorum Quenching QS inhibitors biofilm formation quorum quenching Autoinducer Bacteria |
Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Vol 11 (2020) |
ISSN: | 1664-302X |
Popis: | A biofilm is an assemblage of microbial cells attached to a surface and encapsulated in an extracellular polymeric substance (EPS) matrix. The formation of a biofilm is one of the important mechanisms of bacterial resistance, which not only leads to hard-to-control bacterial infections in humans and animals but also enables bacteria to be a major problem in various fields, such as food processing, wastewater treatment and metalworking. Quorum sensing (QS) is a bacterial cell-to-cell communication process that depends on the bacterial population density and is mediated by small diffusible signaling molecules called autoinducers (AIs). Bacteria use QS to regulate diverse arrays of functions, including virulence and biofilm formation. Therefore, the interference with QS by using QS inhibiting agents, including QS inhibitors (QSIs) and quorum quenching (QQ) enzymes, to reduce or even completely repress the biofilm formation of pathogenic bacteria appears to be a promising approach to control bacterial infections. In this review, we summarize the mechanisms of QS-regulating biofilm formation and QS-inhibiting agents that control bacterial biofilm formation, strategies for the discovery of new QS inhibiting agents, and the current applications of QS-inhibiting agents in several fields to provide insight into the development of effective drugs to control pathogenic bacteria. |
Databáze: | OpenAIRE |
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