Small non coding RNAs in adipocyte biology and obesity

Autor: Ez-Zoubir Amri, Marcel Scheideler
Přispěvatelé: Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
[SDV]Life Sciences [q-bio]
Adipocytes
White
Adipose tissue
Type 2 diabetes
MESH: Energy Intake
Bioinformatics
Biochemistry
Endocrinology
RNA
Transfer
Gene expression
MESH: Obesity
MESH: Animals
Small nucleolar RNA
MESH: Adipocytes
Brown
Adipogenesis
Adipocyte
microRNA
Non-coding RNA
MESH: Gene Expression Regulation
3. Good health
Adipocytes
Brown
Adipose Tissue
MESH: Adipose Tissue
MESH: RNA
Small Nucleolar
Biology
snoRNA
03 medical and health sciences
medicine
Animals
Humans
RNA
Small Nucleolar
Obesity
Molecular Biology
tRNA
Small non-coding RNA
MESH: Humans
Small Non-coding Rna
Microrna
Snorna
Trna
medicine.disease
MESH: RNA
Transfer
MESH: Adipocytes
White
MicroRNAs
030104 developmental biology
Gene Expression Regulation
MESH: Biomarkers
Human genome
Energy Intake
MESH: Adipogenesis
MESH: MicroRNAs
Biomarkers
Function (biology)
Zdroj: Mol. Cell. Endocrinol. 456, 87-94 (2017)
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2017, 456, pp.87-94. ⟨10.1016/j.mce.2017.04.009⟩
ISSN: 0303-7207
DOI: 10.1016/j.mce.2017.04.009⟩
Popis: International audience; Obesity has reached epidemic proportions world-wide and constitutes a substantial risk factor for hypertension, type 2 diabetes, cardiovascular diseases and certain cancers. So far, regulation of energy intake by dietary and pharmacological treatments has met limited success. The main interest of current research is focused on understanding the role of different pathways involved in adipose tissue function and modulation of its mass. Whole-genome sequencing studies revealed that the majority of the human genome is transcribed, with thousands of non-protein-coding RNAs (ncRNA), which comprise small and long ncRNAs. ncRNAs regulate gene expression at the transcriptional and post-transcriptional level. Numerous studies described the involvement of ncRNAs in the pathogenesis of many diseases including obesity and associated metabolic disorders. ncRNAs represent potential diagnostic biomarkers and promising therapeutic targets. In this review, we focused on small ncRNAs involved in the formation and function of adipocytes and obesity.
Databáze: OpenAIRE
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