The role of endocannabinoids in pregnancy
| Autor: | Zdeněk Laštůvka, Simona Mašková, Antonín Pařízek, Josef Suchopár, Miroslava Alblová |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Prostaglandin Early pregnancy factor Bioinformatics chemistry.chemical_compound Pregnancy medicine Humans Childbirth Embryo Implantation biology business.industry Infant Newborn Obstetrics and Gynecology Placentation Anandamide medicine.disease Endocannabinoid system chemistry Pregnancy Maintenance Prostaglandins biology.protein Premature Birth Female lipids (amino acids peptides and proteins) business Endocannabinoids |
| Zdroj: | Česká gynekologie. 86:349-354 |
| ISSN: | 1805-4455 1210-7832 |
| DOI: | 10.48095/cccg2021349 |
| Popis: | Objective: In this paper, we summarize the role of the endocannabinoid system in relation to pregnancy and childbirth and its potential for dia gnosis of preterm birth. Methods: Review of articles in peer-reviewed journals using the PubMed database. Results: Endocannabinoid system plays a signifi cant role in embryo development, transport and implantation as well as in placentation. It consists of numerous endogenous ligands; however, in relation to pregnancy there are mainly two studied representatives: anandamide and 2-arachidonoylglycerol. There is increasing evidence, in addition to early pregnancy events, that anandamide plays a regulatory role in pregnancy maintenance and the timing of labour. The activity of anandamide depends on its metabolic pathway and the enzymatic activity that ensures its conversion. Ultimately, changes in anandamide concentration lead to increased production of prostaglandins or prostamides, with inverse eff ects on pregnancy. The abuse of exogenous cannabinoids in pregnancy has substantial impact on the unborn child in many ways and may result in detrimental eff ects including preterm birth. Conclusion: Measuring anandamide concentration and the prostaglandin to prostamide ratio could be a useful tool in assessing the risk of preterm birth. Key words: endocannabinoid system – pregnancy – labour |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|