Matrix Metalloproteinases in Non-Neoplastic Disorders

Autor: Michihisa Jougasaki, Akinori Tokito
Rok vydání: 2016
Předmět:
0301 basic medicine
Chemokine
matrix metalloproteinase
Non neoplastic
Digestive System Diseases
Arthritis
Inflammation
Review
Disease
Biology
Matrix metalloproteinase
Catalysis
lcsh:Chemistry
Inorganic Chemistry
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
non-neoplastic disease
Organic Chemistry
Cancer
Neurodegenerative Diseases
General Medicine
Respiration Disorders
medicine.disease
Matrix Metalloproteinases
Extracellular Matrix
Computer Science Applications
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Cardiovascular Diseases
Immunology
Cancer research
biology.protein
Kidney Diseases
medicine.symptom
therapeutic potential
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences, Vol 17, Iss 7, p 1178 (2016)
International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: 10.3390/ijms17071178
Popis: The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and they and their substrates are widely expressed in many tissues. Recent growing evidence has established that MMP not only can degrade a variety of components of extracellular matrix, but also can cleave and activate various non-matrix proteins, including cytokines, chemokines and growth factors, contributing to both physiological and pathological processes. In normal conditions, MMP expression and activity are tightly regulated via interactions between their activators and inhibitors. Imbalance among these factors, however, results in dysregulated MMP activity, which causes tissue destruction and functional alteration or local inflammation, leading to the development of diverse diseases, such as cardiovascular disease, arthritis, neurodegenerative disease, as well as cancer. This article focuses on the accumulated evidence supporting a wide range of roles of MMPs in various non-neoplastic diseases and provides an outlook on the therapeutic potential of inhibiting MMP action.
Databáze: OpenAIRE
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