Just not cosmesis! Role of low-density lipoprotein apheresis in familial hypercholesterolemia: Experience at a newly developed tertiary care institution in Northern India
| Autor: | Riti Bhatia, Saikat Mandal, Sheetal Malhotra, Rohit Walia, Ashish Jain, Sushant Kumar Meinia, Daljit Kaur, Gita Negi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Ldl cholesterol
medicine.medical_specialty low-density lipoprotein cholesterol familial hypercholesterolemia Atherosclerotic cardiovascular disease business.industry xanthomas Cosmesis Case Report Hematology Familial hypercholesterolemia medicine.disease Cardiovascular disease Tertiary care lipoprotein apheresis Apheresis LDL apheresis Internal medicine medicine Immunology and Allergy Diseases of the blood and blood-forming organs lipids (amino acids peptides and proteins) Low density lipoprotein apheresis RC633-647.5 business |
| Zdroj: | Asian Journal of Transfusion Science Asian Journal of Transfusion Science, Vol 15, Iss 1, Pp 104-108 (2021) |
| ISSN: | 1998-3565 0973-6247 |
| Popis: | Familial hypercholesterolemia (FH) is characterized by an increase in plasma low-density lipoprotein-cholesterol (LDL-C) levels. It presents with tendon/skin xanthomas and premature atherosclerotic cardiovascular disease. The most available treatment options for FH are lipid-lowering medications such as statins, lifestyle modification, and LDL apheresis. As per American Society for Apheresis guidelines 2019, the treatment of FH using LDL apheresis falls under Category I. Here, we are reporting an interesting case of a young patient who presented with chief complaints of progressively increasing yellowish lesions around eyes, neck, hands, and legs. She was thoroughly investigated and was diagnosed provisionally as a case of Type 2 FH. Her total serum cholesterol and LDL-C were 717.2 mg/dl and 690.6 mg/dl, respectively, at presentation. One cycle of LDL apheresis was planned for her. We found immediate post-procedural reduction of 55.8% and 55.3% for total serum and LDL cholesterol levels respectively while 70.58% and 77.41% reduction in the levels from the day of presentation to the hospital. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|