Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea
| Autor: | Malick Minkael Sylla, Alexandre Delamou, Alassane Dicko, A. Touré, Abdoul Habib Beavogui, Issaka Sagara, Ahmadou Hamidou Togo, Daouda Camara, Abdoulaye Djimde, Abdoulaye Doumbouya, Sekou Toure, Mamadou Saliou Diallo |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Rural Population Percentile Article Subject Adolescent Cross-sectional study 030231 tropical medicine Population Physiology Mean corpuscular hemoglobin Context (language use) General Biochemistry Genetics and Molecular Biology Leukocyte Count 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Reference Values Humans Medicine Aspartate Aminotransferases 030212 general & internal medicine Child education education.field_of_study Creatinine General Immunology and Microbiology medicine.diagnostic_test business.industry Alanine Transaminase General Medicine Middle Aged medicine.disease Cross-Sectional Studies chemistry Cohort Female Guinea business Malaria Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2020 (2020) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2020/8605485 |
| Popis: | Guinea’s reference ranges for biological parameters rely on those of Caucasian values. Variability in reference ranges according to the context is well-documented. We conducted this study for the purpose of future malaria clinical trials that assess the efficacy and safety of malaria drugs. A repeated cross-sectional study was carried out, in an apparently healthy cohort population. Surveys took place in Maferinyah rural community, which is located at 75 km from the capital. The 2.5thand 97.5thpercentiles were determined nonparametrically and stood for reference intervals. Reference values were determined separately for males and females according to ranges of age (6-10 years of age; 11-15 years of age; 16-45 years of age). Differences between genders were tested using the Mann-Whitney test, while the Friedman test was performed to test differences within each gender group according to the seasons. A total of 450 volunteers were enrolled. The median age was 13. Males 16-45 years of age had significantly higher hematologic and biochemical values compared to a female of the same age (for hematological parameters: Mean Cell Hemoglobin Concentration MCHCp≤0.001, Plateletsp≤0.001, monocytesp=0.0305, eosinophilsp=0.0225; for biochemical parameters: Aspartate aminotransferase ASTp≤0.001, Alanine Aminotransferase ALTp≤0.001, creatininep≤0.001). We noticed significant seasonal variations for all the biochemical parameters and some hematologic parameters (Mean Corpuscular Hemoglobin MCH, MCHC, Mean Cell volume). This is the first study establishing hematologic and biochemical parameters in Guinea. These findings provide a useful guide for the clinical researchers and care providers. Studies on large scale and in different settings would be also desirable. |
| Databáze: | OpenAIRE |
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