N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor
| Autor: | Laurence Dube, Ian Egle, Jack Peragine, Keith Jarvie, Jalaj Arora, Ashok Tehim, Michel Bordeleau, Lucy Mazzocco |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adrenergic receptor
Stereochemistry Dopamine Clinical Biochemistry Pharmaceutical Science Ligands Biochemistry Chemical synthesis Drug Discovery medicine Serotonin 5-HT2 Receptor Antagonists Humans Receptor Molecular Biology Chemistry Ligand Organic Chemistry Receptors Dopamine D4 Benzamides Molecular Medicine Serotonin Selectivity medicine.drug Antipsychotic Agents |
| Zdroj: | Bioorganicmedicinal chemistry letters. 15(23) |
| ISSN: | 0960-894X |
| Popis: | A series of N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D(4) (hD(4)) and 5-HT(2A) receptors. Several compounds displayed selectivity for these receptors versus hD(2) and alpha(1) adrenergic receptors of over 500-fold. |
| Databáze: | OpenAIRE |
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