Malarial toxic antigens synergistically enhance insulin signalling
| Autor: | Rachel Carr, J. H. L. Playfair, Kathryn M Taylor, E.David Saggerson |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Lipolysis Plasmodium falciparum Biophysics Antigens Protozoan Mice Inbred Strains In Vitro Techniques Biochemistry Rats Sprague-Dawley chemistry.chemical_compound Mice Structural Biology In vivo Internal medicine Adipocyte parasitic diseases Genetics medicine Animals Insulin Molecular Biology biology Lipogenesis Cell Biology biology.organism_classification medicine.disease Lipids Hypoglycemia Malaria Rats Endocrinology chemistry Adipose Tissue Cerebral Malaria Female Plasmodium yoelii Signal Transduction |
| Zdroj: | FEBS letters. 311(3) |
| ISSN: | 0014-5793 |
| Popis: | Hypoglycaemia is a major complication of severe malaria [(1990) Trans. Roy. Soc. Trop. Med. 84 (suppl. 2) 1–65], especially cerebral malaria, in which it is associated with increased mortality [(1990) Lancet 336, 1039–1043; (1989) Quart. J. Med. (New series) 71, 441–459]; however, the mechanisms responsible have not been fully explained. Preparations containing toxic malaria antigens (TMA) released by blood stage Plasmodium yoelii malaria parasites have been shown to induce hypoglycaemia in mice lasting at least 8 h [(1992) Clin. Exp. Immunol. (in press)]. Here we report that TMAs can act synergistically with insulin in both stimulating lipogenesis and inhibiting lipolysis in rat adipocytes in vitro, and, furthermore, that they act synergistically with insulin in the induction of hypoglycaemia in vivo. |
| Databáze: | OpenAIRE |
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