BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice
| Autor: | R.L. Mosley, N. Yotam, T. Rinat, J.M. McMillan, Howard E. Gendelman, Jessica A L Hutter-Saunders, Lisa M. Kosloski |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Levodopa Parkinson's disease Cell Survival Motor Activity Pharmacology Neuroprotection Article gamma-Aminobutyric acid Lesion Mice chemistry.chemical_compound Parkinsonian Disorders Dopamine medicine Animals gamma-Aminobutyric Acid Neurons Behavior Animal business.industry General Neuroscience MPTP Dopaminergic Brain medicine.disease Immunohistochemistry nervous system diseases Mice Inbred C57BL Drug Combinations Neuroprotective Agents nervous system chemistry medicine.symptom business Neuroscience medicine.drug |
| Zdroj: | Neuroscience. 180:293-304 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2011.02.015 |
| Popis: | The therapeutic potential of BL-1023, a chemical combination of l -3,4-dihydroxyphenylalanine ( l -DOPA) and gamma-aminobutyric acid (GABA), was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxicated mice. Such animals exhibit nigrostriatal degeneration, characteristic of human Parkinson's disease. Drug was administered during and after the development of MPTP-induced nigrostriatal lesions followed by measures of motor function and behavior, surviving nigrostriatal dopaminergic neurons and termini, and striatal dopamine levels. When administered after lesion development, BL-1023 improved motor function of MPTP-mice as measured by rotarod, total floor and vertical plane movements, and stereotypic movements in open field activity tests compared to MPTP-mice without treatment. This also paralleled modest nigral dopaminergic neuronal protection. Such significant improvements in motor function, behaviors, and dopaminergic neuronal numbers were not seen when BL-1023 was administered during MPTP-induced lesion development. The data demonstrate select abilities of BL-1023 to increase dopaminergic neuronal survival and improve motor function in MPTP-mice. |
| Databáze: | OpenAIRE |
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