Erythrocytes are oxygen-sensing regulators of the cerebral microcirculation
| Autor: | Izad-Yar D. Rasheed, Chris Xu, Helen S. Wei, Kristopher Emil Richardson, Sitong Zhou, Andre F. Palmer, Hongyi Kang, Evan McConnell, Anna Gershteyn, Yixuan Wang, Nanhong Lou, Jiandi Wan |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Erythrocytes Capillary action 1.1 Normal biological development and functioning chemistry.chemical_element Hyperemia Biology Neurotransmission Oxygen Article Microcirculation 03 medical and health sciences Mice 0302 clinical medicine Underpinning research Neuropil medicine Psychology Premovement neuronal activity Animals Neurology & Neurosurgery General Neuroscience Neurosciences Brain Blood flow 030104 developmental biology medicine.anatomical_structure Cerebral blood flow chemistry Neurological Biophysics Cognitive Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron, vol 91, iss 4 |
| Popis: | Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. Invivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Exvivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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