Transient Decrease in Circulatory Testosterone and Homocysteine Precedes the Development of Metabolic Syndrome Features in Fructose-Fed Sprague Dawley Rats
| Autor: | Sai Santosh Vadakattu, Sujatha Pitla, Siva Sankara Vara Prasad Sakamuri, Anil Sakamuri, Uday Kumar Putcha, Ahamed Ibrahim, Sugeedha Jayapal, Nagabhushan Reddy Konapalli, Sailaja Pothana |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Homocysteine Article Subject Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology 03 medical and health sciences chemistry.chemical_compound Insulin resistance Internal medicine medicine lcsh:RC620-627 Testosterone Nutrition and Dietetics Triglyceride Insulin Hypertriglyceridemia Fructose medicine.disease lcsh:Nutritional diseases. Deficiency diseases 030104 developmental biology Endocrinology chemistry Metabolic syndrome Research Article Food Science |
| Zdroj: | Journal of Nutrition and Metabolism, Vol 2016 (2016) Journal of Nutrition and Metabolism |
| ISSN: | 2090-0724 |
| DOI: | 10.1155/2016/7510840 |
| Popis: | Background. Increased fructose consumption is linked to the development of metabolic syndrome (MS). Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels.Methods. Rats were divided into control and experimental groups and fed with diets containing 54.5% starch and fructose, respectively, for 4, 12, and 24 weeks. Plasma testosterone and homocysteine levels were measured along with insulin, glucose, and lipids. Body composition, insulin resistance, and hepatic lipids were measured.Results. Increase in hepatic triglyceride content was first observed in metabolic disturbance followed by hypertriglyceridemia and systemic insulin resistance in fructose-fed rats. Hepatic lipids were increased in time-dependent manner by fructose-feeding starting from 4 weeks, but circulatory triglyceride levels were increased after 12 weeks. Fasting insulin and Homeostatis Model Assessment of Insulin Resistance (HOMA-IR) were increased after 12 weeks of fructose-feeding. Decreased visceral adiposity, circulatory testosterone, and homocysteine levels were observed after 4 weeks of fructose-feeding, which were normalized at 12 and 24 weeks.Conclusions. We conclude that transient decrease in circulatory testosterone and homocysteine levels and increased hepatic triglyceride content are the earliest metabolic disturbances that preceded hypertriglyceridemia and insulin resistance in fructose-fed SD rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|