A simulation study on using 252Cf for the treatment of esophagus tumor in human phantom
| Autor: | Hasan Bakhshandeh, S. Mohsen Salehkoutahi, Fatemeh S. Rasouli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
lcsh:R895-920 medicine.medical_treatment Monte Carlo method Brachytherapy Biomedical Engineering Normal tissue Healthy tissue Esophagus tumors Neutron brachytherapy Esophagus tumor Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Radiology Nuclear Medicine and imaging Esophagus 252Cf source Instrumentation Monte Carlo simulation Original Research Radiation business.industry medicine.anatomical_structure Dose 030220 oncology & carcinogenesis Neutron source Nuclear medicine business |
| Zdroj: | EJNMMI Physics, Vol 7, Iss 1, Pp 1-12 (2020) EJNMMI Physics |
| ISSN: | 2197-7364 |
| DOI: | 10.1186/s40658-020-00341-8 |
| Popis: | Due to the sensitivity of this tissue, and the potential for metastasis of its cancer as well, finding accurate methods to be employed for the treatment of esophagus tumors is of especial interest for the researchers. The present study deals with a Monte Carlo simulation of 252Cf neutron brachytherapy for treating these tumors using MCNPX (Version 2.6.0) code. The widely accepted AAPM TG-43 protocol has been used to benchmark the simulated source and to examine the accuracy of the modeling. The MIRD human phantom has been used for dose evaluation in the mentioned tumor and in the surrounding normal tissues as well. To decrease the dose delivered to the healthy tissue, using appropriate shields has been proposed. Through dosimetric calculations for several candidates, Pt-Ir 10% with a thickness of 1 cm has been selected as the optimized shield. The depth-dose results as well as the isodose curves corresponding to the presence of the shielded 252Cf neutron source in the center of the simulated tumor offer this source as an appropriate candidate to be used for the treatment of the esophagus tumors and sparing normal tissues. For a suggested clinical condition of positioning the source inside the esophagus, the damage to the first depth in spine can be avoided by managing the treatment time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink