Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids
| Autor: | Kamel Benakli, Eric Marsault, Graeme L. Fraser, Robert Deziel, Carl Saint-Louis, Sylvie Beaubien |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Receptors Neuropeptide Macrocyclic Compounds Chemistry Peptidomimetic Stereochemistry Motilin receptor Organic Chemistry Clinical Biochemistry Pharmaceutical Science Peptide Tripeptide Biochemistry Chemical synthesis Small molecule Motilin Amino acid Receptors Gastrointestinal Hormone Cyclization Drug Discovery Molecular Medicine Amino Acids Molecular Biology |
| Zdroj: | Bioorganicmedicinal chemistry letters. 17(15) |
| ISSN: | 0960-894X |
| Popis: | Novel, potent small molecule motilin receptor antagonists are described. These peptidomimetic macrocycles are composed of a tripeptide cyclized backbone-to-backbone with a nonpeptidic tether and bear new unnatural amino acids containing basic side chains. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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