Prenylated Diresorcinols Inhibit Bacterial Quorum Sensing
| Autor: | Aleksandra I. Noras, Cynthia S. Day, Mario Augustinović, Kathleen D. Triplett, Nicholas H. Oberlies, Mario Figueroa, Pamela R. Hall, Huzefa A. Raja, Nadja B. Cech, Daniel A. Todd, José Rivera-Chávez, Justin J. Stempin, Noemi D. Paguigan |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.drug_class
Antibiotics Pharmaceutical Science Virulence Fungus Bacterial growth 01 natural sciences Analytical Chemistry Microbiology Prenylation Drug Discovery medicine Pharmacology Bacteria biology 010405 organic chemistry Chemistry Organic Chemistry Fungi Quorum Sensing Resorcinols biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Quorum sensing Helotiales Complementary and alternative medicine Molecular Medicine |
| Zdroj: | Journal of Natural Products. 82:550-558 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.8b00925 |
| Popis: | Current treatment options for bacterial infections are dependent on antibiotics that inhibit microbial growth and viability. These approaches result in the evolution of drug-resistant strains of bacteria. An anti-infective strategy that is less likely to lead to the development of resistance is the disruption of quorum sensing mechanisms, which are involved in promoting virulence. The goal of this study was to identify fungal metabolites effective as quorum sensing inhibitors. Three new prenylated diresorcinols (1-3), along with two known compounds, (4 R) -regiolone and decarboxycitrinone, were isolated from a freshwater fungus (Helotiales sp.) from North Carolina. Their structures were assigned on the basis of HRESIMS and NMR experiments. The structure of compound 1 was confirmed via X-ray diffraction analysis, and its absolute configuration was established by TDDFT-ECD and optical rotation calculations. Compounds 1-3 suppressed quorum sensing in a clinical isolate of methicillin-resistant Staphylococcus aureus (MRSA), with IC |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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