Slow-release vaginal insert of misoprostol versus orally administrated solution of misoprostol for the induction of labour in primiparous term pregnant women: a randomised controlled trial
| Autor: | Hans Järnbert-Pettersson, Kristina Gemzell-Danielsson, M Friman-Mathiasson, M Strandberg, C Pilo, Tove Wallstrom, Eva Wiberg-Itzel |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Cardiotocography Term Birth medicine.medical_treatment Population Bishop score Administration Oral Pregnancy Oxytocics medicine Fetal distress Humans Caesarean section Labor Induced education Misoprostol Sweden education.field_of_study Obstetrics Vaginal delivery business.industry Cephalic presentation Infant Newborn Obstetrics and Gynecology medicine.disease Delivery Obstetric Administration Intravaginal Parity Treatment Outcome Delayed-Action Preparations Apgar Score Apgar score Female business medicine.drug |
| Zdroj: | BJOG : an international journal of obstetrics and gynaecology. 126(9) |
| ISSN: | 1471-0528 |
| Popis: | OBJECTIVE To compare the World Health Organization (WHO) recommended orally administrated dosage of misoprostol (25 μg) with a vaginal slow-release (7 μg/hour) insert of misoprostol regarding time from induction to delivery and safety of the method. DESIGN Open label, Randomised controlled trial (RCT). SETTING Delivery ward at a secondary referral hospital in Stockholm, Sweden, from 1 October 2016 to 21 February 2018. POPULATION One hundred and ninety-six primiparous women with singletons in cephalic presentation at ≥37 weeks of gestation and with a Bishop score of ≤4. METHODS Women were randomised to an oral solution of misoprostol (Cytotec® n = 99) or vaginal slow-release misoprostol (Misodel® [MVI] n = 97). MAIN OUTCOME MEASURES Primary outcome: time from induction to vaginal delivery. SECONDARY OUTCOMES mode of delivery; proportion of vaginal deliveries within 24 hours (VD24); neonates with an Apgar score of 1000 ml; hyperstimulation; and women's delivery experience (VAS). RESULTS There was no difference in the time to delivery [corrected] (median 21.1 hours in the MVI group and 23.2 hours in the oral group; Kaplan-Mayer log rank P = 0.31). There was no difference regarding the proportion of VD24 (50.5 versus 55.7%, P = 0.16). Hyperstimulation with non-reassuring cardiotocography (CTG) was more common in the MVI group (14.4 versus 3.0%, P |
| Databáze: | OpenAIRE |
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