Lifestyle advice follow-up improve glycemic control, redox and inflammatory status in patients with type 2 diabetes
| Autor: | F Boukortt, Zakaria Benzian, Nadia Mahdad, Malika Bouchenak |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
HbA1c Dietary composition business.industry Endocrinology Diabetes and Metabolism Insulin sensitivity Type 2 diabetes medicine.disease Endocrinology Redox status Lifestyle advice TNF-α Internal medicine Diabetes mellitus Internal Medicine medicine Resistin In patient business Research Article Glycemic |
| Zdroj: | Journal of Diabetes and Metabolic Disorders |
| ISSN: | 2251-6581 |
| DOI: | 10.1186/s40200-014-0122-1 |
| Popis: | Background The dietary composition associated to physical activity could play a significant role in improving insulin sensitivity and reducing risk of diabetes and its complications. This study was designed to investigate whether glycemic control, redox and inflammatory status impairments in patients with type 2 diabetes (T2D), were improved after 90 (d90) and 180 (d180) days follow-up of nutritional advices. Methods Patients with T2D (n = 85) aged of 50 ± 8 years (Female/Male, 45/40), treated with oral antidiabetics (OAD) alone, with a body mass index (BMI) of 26 ± 2, were recruited. At the beginning of the study (d0), patients were instructed to follow-up nutritional advices adapted to T2D, and 30 to 45 min of walking per day. Assays were realized at d90 and d180 of follow-up. Data were compared by student ‘t’ test and Pearson’s correlation coefficients were determined between biochemical parameters and nutritional advices follow-up. Results Reduced glycated haemoglobin (HbA1c), glucose and total cholesterol (TC) were noted in patients with T2D, at d90 and d180 compared to d0. Thiobarbituric acid reactive substances (TBARS) and hydroperoxyde levels were lower at d90 and d180 than d0. Serum nitric oxide (NO) was decreased at d180 compared to d0 and d90. In erythrocytes, superoxide dismutase (SOD) activity increased by 7% at d180 vs d0. Moreover, activity of glutathione peroxidase (GPx) enhanced (P |
| Databáze: | OpenAIRE |
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