Test type influences the expression of lithium chloride-induced hyperalgesia
| Autor: | Westbrook Rf, Gavan P. McNally |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
inorganic chemicals
Male Formalin Test Hot Temperature Clinical Biochemistry Analgesic Pharmacology Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Antimanic Agents Immersion medicine Noxious stimulus Avoidance Learning Reaction Time Animals Rats Wistar Biological Psychiatry Pain Measurement Dose-Response Relationship Drug Chemistry food and beverages equipment and supplies Rats Nociception Hyperalgesia Anesthesia Morphine Lithium chloride medicine.symptom Lithium Chloride Tail flick test medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 61(4) |
| ISSN: | 0091-3057 |
| Popis: | The hyperalgesic properties of the emetic drug lithium chloride (LiCl) were examined in eight experiments. At a dose of 63.6 mg/kg, LiCl produced hyperalgesia in the radiant-heat (Experiment 1a) and immersion (Experiment 1b) tail-flick tests. At doses of 15.9, 31.8, 63.6, and 127.2 mg/kg, LiCl failed to produce hyperalgesia during the delayed behavioral response in the formalin test (Experiments 2a and 2b), but 63.6 mg/kg LiCl did produce hyperalgesia during the normally quiescent, interphase period of formalin responding (Experiment 2c). At the dose of 63.6 mg/kg, LiCl did not produce hyperalgesia in the hotplate test (Experiments 3a and 3b) and did not exert significant motoric effects in a step-down passive-avoidance task (Experiment 4). The results were discussed with reference to the behavioral effects of LiCl and their implications for demonstrations of associatively mediated morphine analgesic tolerance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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