Targeting the fungal cell wall: current therapies and implications for development of alternative antifungal agents
| Autor: | Sahar Hasim, Jeffrey J. Coleman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
Antifungal Antifungal Agents Future studies medicine.drug_class media_common.quotation_subject Antifungal drugs Antifungal drug Review 01 natural sciences Microbiology Cell wall 03 medical and health sciences High morbidity Cell Wall Drug Discovery Animals Humans Medicine Molecular Targeted Therapy 030304 developmental biology media_common Pharmacology 0303 health sciences business.industry Fungi 0104 chemical sciences 010404 medicinal & biomolecular chemistry Mycoses Drug development Molecular Medicine business |
| Zdroj: | Future Medicinal Chemistry. 11:869-883 |
| ISSN: | 1756-8927 1756-8919 |
| DOI: | 10.4155/fmc-2018-0465 |
| Popis: | Fungal infections are a worldwide problem associated with high morbidity and mortality. There are relatively few antifungal agents, and resistance has emerged within these pathogens for the newest antifungal drugs. As the fungal cell wall is critical for growth and development, it is one of the most important targets for drug development. In this review, the currently available cell wall inhibitors and suitable drug candidates for the treatment of fungal infections are explored. Future studies of the fungal cell wall and compounds that have detrimental effects on this important outer structural layer could aid in antifungal drug discovery and lead to the development of alternative cell wall inhibitors to fill gaps in clinical therapies for difficult-to-treat fungal infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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