Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy
| Autor: | Mette Hansen Viuff, Jesper Just, Sara Brun, Tine Vrist Dam, Mette Hansen, Lars Melgaard, David M Hougaard, Michael Lappe, Claus Højbjerg Gravholt |
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| Rok vydání: | 2022 |
| Předmět: |
Estradiol
Gonadal Steroid Hormones/therapeutic use Estrogens/deficiency Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Turner Syndrome Estrogens Luteinizing Hormone Androgens/deficiency Turner Syndrome/drug therapy Progesterone/therapeutic use Biochemistry Endocrinology Sex Hormone-Binding Globulin Androgens Sex Hormone-Binding Globulin/analysis Humans Female Testosterone Sex hormones Follicle Stimulating Hormone Gonadal Steroid Hormones Progesterone |
| Zdroj: | Viuff, M H, Just, J, Brun, S, Dam, T V, Hansen, M, Melgaard, L, Hougaard, D M, Lappe, M & Gravholt, C H 2022, ' Women With Turner Syndrome Are Both Estrogen and Androgen Deficient : The Impact of Hormone Replacement Therapy ', The Journal of clinical endocrinology and metabolism, vol. 107, no. 7, pp. 1983-1993 . https://doi.org/10.1210/clinem/dgac167 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgac167 |
| Popis: | Context Women with Turner syndrome (TS) suffer from hypergonadotropic hypogonadism, causing a deficit in gonadal hormone secretion. As a consequence, these women are treated with estrogen from the age of 12 years, and later in combination with progesterone. However, androgens have been given less attention. Objective To assess sex hormone levels in women with TS, both those treated and those nontreated with hormone replacement therapy (HRT), and investigate the impact of HRT on sex hormone levels. Methods At Aarhus University Hospital, 99 women with TS were followed 3 times from August 2003 to February 2010. Seventeen were lost during follow-up. Control group 1 consisted of 68 healthy age-matched control women seen once during this period. Control group 2 consisted of 28 young, eumenorrheic women sampled 9 times throughout the same menstrual cycle. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol, estrone sulfate, DHEAS, testosterone, free androgen index, androstenedione, 17-OH progesterone, and sex hormone–binding globulin (SHBG) were analyzed. Results All androgens, 17-OH progesterone, and sex hormone–binding globulin (SHBG) were 30% to 50% lower in TS compared with controls (P < 0.01). FSH, LH, and estrone sulfate were more than doubled in women with TS compared with controls (P < 0.02). Using principal component analysis, we describe a positive correlation between women with TS receiving HRT, elevated levels of SHBG, and decreased levels of androgens. Conclusion The sex hormone profile in TS reveals a picture of androgen deficiency, aggravated further by HRT. Conventional HRT does not normalize estradiol levels in TS. |
| Databáze: | OpenAIRE |
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