Effect of completion-time windows in the analysis of health-related quality of life outcomes in cancer patients
| Autor: | E.F. Smit, Madeleine King, C. Quinten, Efstathios Zikos, Henning Flechtner, Corneel Coens, J. Schmucker von Koch, Andrew Bottomley, C.-H. Köhne, Joachim Weis, Carolyn C. Gotay, Jolie Ringash, Divine E. Ediebah, J. Maringwa |
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| Přispěvatelé: | Pulmonary medicine, CCA - Quality of life |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Health related quality of life medicine.medical_specialty Lung Neoplasms Randomization business.industry Colorectal cancer Specific time Cancer Original Articles Hematology medicine.disease Chemotherapy regimen humanities Surgery Quality of life Carcinoma Non-Small-Cell Lung Internal medicine Quality of Life Humans Medicine Completion time Colorectal Neoplasms business |
| Zdroj: | Annals of Oncology, 24(1), 231-237. Oxford University Press Ediebah, D E, Coens, C, Maringwa, J T, Quinten, C, Zikos, E, Ringash, J, King, M, Gotay, C, Flechtner, H H, von Koch, J S, Weis, J, Smit, E F, Kohne, C H & Bottomley, A 2013, ' Effect of completion-time windows in the analysis of health-related quality of life outcomes in cancer patients ', Annals of Oncology, vol. 24, no. 1, pp. 231-237 . https://doi.org/10.1093/annonc/mds220 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mds220 |
| Popis: | BACKGROUND We examined if cancer patients' health-related quality of life (HRQoL) scores on the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 are affected by the specific time point, before or during treatment, at which the questionnaire is completed, and whether this could bias the overall treatment comparison analyses. PATIENTS AND METHODS A 'completion-time window' variable was created on three closed EORTC randomised control trials in lung (non-small cell lung cancer, NSCLC) and colorectal cancer (CRC) to indicate when the QLQ-30 was completed relative to chemotherapy cycle dates, defined as 'before', 'on' and 'after'. HRQoL mean scores were calculated using a linear mixed model. RESULTS Statistically significant differences (P |
| Databáze: | OpenAIRE |
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