Association of IL-13 rs20541 and rs1295686 variants with symptomatic asthma in a Saudi Arabian population
| Autor: | Alejandro Vazquez-Tello, Zahid Shakoor, Rabih Halwani, Saleh Al-Muhsen, Rosan Kenana, Maram Al-Otaibi, Khalid Alhasan |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Hypersensitivity Immediate Male 0301 basic medicine Pulmonary and Respiratory Medicine Allergy Adolescent Genotype Population Saudi Arabia Single-nucleotide polymorphism Polymorphism Single Nucleotide Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine immune system diseases medicine Humans Immunology and Allergy Child education Atopic asthma Genotyping Alleles Aged Genetic association Asthma education.field_of_study Interleukin-13 business.industry Age Factors Immunoglobulin E Middle Aged medicine.disease respiratory tract diseases Cross-Sectional Studies 030104 developmental biology Socioeconomic Factors 030228 respiratory system Child Preschool Pediatrics Perinatology and Child Health Interleukin 13 Immunology Female business |
| Zdroj: | Journal of Asthma. 55:1157-1165 |
| ISSN: | 1532-4303 0277-0903 |
| DOI: | 10.1080/02770903.2017.1400047 |
| Popis: | Interleukin 13 (IL-13) plays a critical pro-inflammatory role in asthma. Several single nucleotide polymorphisms (SNPs) are associated with asthma susceptibility in specific populations; however, further replicative studies in other ethnic groups are mandatory.The association between IL-13 SNPs rs762534, rs20541, rs1295686, and rs1800925 (risk alleles A, A, T, and A, respectively) and asthma predisposition in a Saudi Arabian cohort was examined via a case-control cross-sectional study.The frequencies of alleles between asthmatics and control populations were significantly different for rs20541 and rs1295686 SNPs (p0.001), whereas the frequencies of genotypes between asthmatics and controls were significantly different only for rs20541. The association of the risk (minor) alleles with asthma was examined using the dominant genetic model. Individuals with at least one copy of the risk alleles A (for rs20541) and T (for rs1295686) had significantly greater odds of being asthmatic (OR = 2.13, 95% CI = 1.39-3.26, p0.0001; OR = 1.69, 95% CI = 1.12-2.54, p = 0.008) relative to their most common homozygous genotypes. On the other hand, the minor A alleles for rs762534 and rs1800925 were not significantly associated with asthma risk. Regarding haplotype association analysis, individuals with at least one copy of the minor "risk" allele for both rs20541 and rs1295686 (CATG and CATA, respectively) had greater odds of being asthmatic relative to CGCG haplotype; however, this trend was not statistically significant (p0.3).IL-13 minor T and A alleles for rs1295686 and rs20541, respectively, were associated with significantly higher risk of asthma in the Saudi Arabian population. |
| Databáze: | OpenAIRE |
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