Interaction of the renin-angiotensin system and the endothelin system in cardiac hypertrophy
| Autor: | A. C. H. Teisman, Martin Paul, Rainer Dietz, Simone Gschwend, M Stula, W. H. Van Gilst, Michael Böhm, YM Pinto |
|---|---|
| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Cardiomegaly Peptide hormone Biology Endothelin-Converting Enzymes Left ventricular hypertrophy Muscle hypertrophy Animals Genetically Modified Rats Sprague-Dawley Renin-Angiotensin System Mice Internal medicine Renin–angiotensin system Renin medicine Animals Aspartic Acid Endopeptidases RNA Messenger Carvedilol Pharmacology Endothelins Metalloendopeptidases Rats Inbred Strains medicine.disease Blotting Northern Rats Losartan Blood pressure Endocrinology Cardiology and Cardiovascular Medicine Endothelin receptor medicine.drug |
| Zdroj: | Scopus-Elsevier Journal of cardiovascular pharmacology, 31(Suppl. 1), S403-S405. Lippincott Williams and Wilkins |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-199800001-00116 |
| Popis: | It has been suggested that the renin-angiotensin system (RAS) interacts with the endothelin system in the pathogenesis of cardiac remodeling. We examined endothelin system regulation in a model of chronic RAS dysfunction, which is believed to be an important factor in cardiac remodeling. We used the transgenic rat line TGR(mRen2)27, which overexpresses the mouse Renin-2 gene and shows hypertension and left ventricular hypertrophy compared to Sprague-Dawley (SD) rats. Ren-2 rats (n = 24) received either losartan (LOS), quniapril (QIN), or carvedilol (CARV) for 11 weeks, or no treatment. After 11 weeks left (LV) and right ventricular (RV) weights were determined and total RNA extracted. Ren-2 rats showed a mean systolic blood pressure of 190 mm (+/- SEM), which could be normalized to 110 +/- mm (+/- SEM) by treatment with LOS or QIN. CARV also reduced blood pressure but did not normalize it. LV end-diastolic pressure was normal in both SD and Ren-2 rats. LV weight was increased in the Ren-2 rats compared to SD rats, and was significantly reduced to normal in the LOS and QIN but not in the CARV group. RV weight was normal in all groups. Northern blot analysis of preproendothelin-1 (preproET-1) and endothelin-converting enzyme-1 (ECE-1) expression revealed a significant (p |
| Databáze: | OpenAIRE |
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