Rapid feedback inhibition of endogenous cholic and chenodeoxycholic acid synthesis by exogenous chenodeoxycholic acid in man
| Autor: | Z.Reno Vlahcevic, Leon Swell, L. Gregg Halloran, Charles C. Schwartz |
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| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Feedback inhibition Biophysics Mevalonic Acid Endogeny Mevalonic acid Baseline level Chenodeoxycholic Acid Biochemistry Catheterization Feedback Bile Acids and Salts chemistry.chemical_compound Internal medicine Chenodeoxycholic acid medicine Bile Humans Cholecystectomy Molecular Biology Phospholipids Chemistry Cholic Acids Cell Biology Middle Aged Cholesterol Endocrinology Constant infusion Bile acid synthesis |
| Zdroj: | Biochemical and Biophysical Research Communications. 64:1083-1089 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(75)90158-8 |
| Popis: | Chenodeoxycholic acid (300 mg + 14 C) was administered orally to a bile fistula patient receiving a constant infusion of { 3 H}mevalonic acid. Suppression of endogenous cholic and chenodeoxycholic acid synthesis occurred within 2 to 4 hours and continued for the next 10 hours; synthesis returned to the baseline level after 18 hours. Incorporation of { 3 H}mevalonic acid into both bile acids was also greatly reduced during the first several hours after chenodeoxycholic acid, but almost recovered by 5 hours. The data suggest that multiple feedback sites are involved in the regulation of bile acid synthesis in man. |
| Databáze: | OpenAIRE |
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