Quasi-VMAT in high-grade glioma radiation therapy
| Autor: | Marco Possanzini, Paolo Farace, Gianfranco Meleddu, S. Durzu, Giuseppina Fadda, G. Massazza, Sergio Zucca |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Dose delivery business.industry Brain Neoplasms medicine.medical_treatment Planning target volume Dose distribution Glioma Middle Aged Radiation therapy Conformity index Treatment Outcome Oncology Organ at risk Maximum dose Medicine Humans Radiology Nuclear Medicine and imaging Female Radiotherapy Intensity-Modulated business Nuclear medicine High-Grade Glioma Aged |
| Zdroj: | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 189(5) |
| ISSN: | 1439-099X |
| Popis: | To compare a quasi-volumetric modulated arc therapy (qVMAT) with three-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) for the treatment of high-grade gliomas. The qVMAT technique is a fast method of radiation therapy in which multiple equispaced beams analogous to those in rotation therapy are radiated in succession. This study included 12 patients with a planning target volume (PTV) that overlapped at least one organ at risk (OAR). 3D-CRT was planned using 2–3 non-coplanar beams, whereby the field-in-field technique (FIF) was used to divide each field into 1–3 subfields to shield the OAR. The qVMAT strategy was planned with 15 equispaced beams and IMRT was planned using 9 beams with a total of 80 segments. Inverse planning for qVMAT and IMRT was performed by direct machine parameter optimization (DMPO) to deliver a homogenous dose distribution of 60 Gy within the PTV and simultaneously limit the dose received by the OARs to the recommended values. Finally, the effect of introducing a maximum dose objective (max. dose |
| Databáze: | OpenAIRE |
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