Genetic reassortment of influenza C viruses in man
| Autor: | Kiyoto Nakamura, Gao Peng, Hidekazu Nishimura, Kanetsu Sugawara, Fumio Kitame, Yasushi Muraki, Seiji Hongo |
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| Rok vydání: | 1994 |
| Předmět: |
Antigenicity
Influenzavirus C Genes Viral Human influenza viruses Molecular Sequence Data Reassortment Hemagglutinins Viral Biology Virus Viral Proteins Japan Virus strain Sequence Homology Nucleic Acid Virology Humans Cloning Molecular Gene Base Sequence Nucleic acid sequence Sequence Analysis DNA RNA Viral Influenza C Virus Viral Fusion Proteins Reassortant Viruses |
| Zdroj: | Journal of General Virology. 75:3619-3622 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/0022-1317-75-12-3619 |
| Popis: | We reported previously that the antigenicity of the haemagglutinin-esterase (HE) glycoprotein of the human influenza C virus strain C/Nara/1/85 was indistinguishable from that of strain C/Nara/82. However, the ribonuclease T1-oligonucleotide map of total virion RNA of C/Nara/1/85 differed remarkably from the map of C/Nara/82, resembling instead the map of C/Nara/2/85, which has an HE antigenicity dissimilar to C/Nara/82 and C/Nara/1/85. This observation raised the possibility that C/Nara/1/85 might have arisen by reassortment from two viruses closely related to C/Nara/82 and C/Nara/2/85, respectively. Here, we compared the total nucleotide sequence of the HE gene and partial sequences of the other genes of C/Nara/1/85 with those of C/Nara/82 and C/Nara/2/85. The results suggest that C/Nara/1/85 has inherited HE and NP genes from a C/Nara/82-related virus and the PB2, PB1, PA, M and NS genes from a C/Nara/2/85-related virus. |
| Databáze: | OpenAIRE |
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