Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas
| Autor: | Heike C. Einhellig, Eberhard Siebert, Hans-C. Bauknecht, Anna Tietze, Josefine Graef, Christian Furth, Daniel Schulze, Milena Miszczuk, Georg Bohner, Imke Schatka, Marcus R. Makowski |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male intracranial meningiomas Science Contrast Media Octreotide Article otorhinolaryngologic diseases Meningeal Neoplasms Organometallic Compounds Humans standalone MRI ddc:610 neoplasms Aged Aged 80 and over Molecular medicine Health care Middle Aged Magnetic Resonance Imaging nervous system diseases 68 Ga‑DOTATOC PET/ MRI Neurology Positron-Emission Tomography Medicine Female Anatomy Radiopharmaceuticals 610 Medizin und Gesundheit Meningioma 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit Neuroscience |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| Popis: | To evaluate the diagnostic performance of magnetic resonance imaging (MRI) alone in comparison to positron emission tomography/ magnetic resonance imaging (PET/MRI) in patients with meningiomas. 57 patients with a total of 112 meningiomas of the brain were included. PET/MRI, including a fully diagnostic contrast enhanced MRI and PET, were acquired. PET/MRI was used as reference standard. The size and location of meningiomas was recorded. Likelihood-ratio chi-square tests were used to calculate p-values within logistic regression in order to compare different models. A multi-level logistic regression was applied to comply the hierarchical data structure. Multi-level regression adjusts for clustering in data was performed. The majority (n = 103) of meningiomas could be identified based on standard MRI sequences compared to PET/MRI. MRI alone achieved a sensitivity of 95% (95% CI 0.78, 0.99) and specificity of 88% (95% CI 0.58, 0.98). Based on intensity of contrast medium uptake, 97 meningiomas could be diagnosed with intense uptake (93.75%). Sensitivity was lowest with 74% for meningiomas 2cm3 and highest with 100% for meningiomas 0.5–1.0 cm3. Petroclival meningiomas showed lowest sensitivity with 88% compared to sphenoidal meningiomas with 94% and orbital meningiomas with 100%. Specificity of meningioma diagnostic with MRI was high with 100% for sphenoidal and hemispherical-dural meningiomas and meningiomas with 0.5–1.0 and 1.0–2.0 cm3. Overall MRI enables reliable detection of meningiomas compared to PET/MRI. PET/MRI imaging offers highest sensitivity and specificity for small or difficult located meningiomas. Charité (3093) |
| Databáze: | OpenAIRE |
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