Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels
| Autor: | Hanna Bueno, Asher Peretz, Bernard Attali, David Weisbrod, Shiraz Haron Khun |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Human Embryonic Stem Cells Review 030204 cardiovascular system & hematology Cardiac pacemaker 03 medical and health sciences Pacemaker potential Potassium Channels Calcium-Activated 0302 clinical medicine Biological Clocks Medicine Humans Pharmacology (medical) Myocytes Cardiac Sinoatrial Node Pharmacology business.industry Sinoatrial node General Medicine Diastolic depolarization Intermediate-Conductance Calcium-Activated Potassium Channels Calcium-activated potassium channel Cardiovascular physiology 030104 developmental biology medicine.anatomical_structure Electrical conduction system of the heart NODAL business Neuroscience |
| Zdroj: | Acta pharmacologica Sinica. 37(1) |
| ISSN: | 1745-7254 |
| Popis: | The proper expression and function of the cardiac pacemaker is a critical feature of heart physiology. The sinoatrial node (SAN) in human right atrium generates an electrical stimulation approximately 70 times per minute, which propagates from a conductive network to the myocardium leading to chamber contractions during the systoles. Although the SAN and other nodal conductive structures were identified more than a century ago, the mechanisms involved in the generation of cardiac automaticity remain highly debated. In this short review, we survey the current data related to the development of the human cardiac conduction system and the various mechanisms that have been proposed to underlie the pacemaker activity. We also present the human embryonic stem cell-derived cardiomyocyte system, which is used as a model for studying the pacemaker. Finally, we describe our latest characterization of the previously unrecognized role of the SK4 Ca(2+)-activated K(+) channel conductance in pacemaker cells. By exquisitely balancing the inward currents during the diastolic depolarization, the SK4 channels appear to play a crucial role in human cardiac automaticity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink