Classics in Neuroimaging: Imaging the Cholinergic System with Positron Emission Tomography
| Autor: | Prabesh Kanel, Martijn L.T.M. Müller, Hailey K Gross, Nicolaas I. Bohnen, Michael R. Kilbourn, Peter J. H. Scott, Alexandra R. Sowa Dumond, Robert A. Koeppe |
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| Rok vydání: | 2021 |
| Předmět: |
Physiology
Cognitive Neuroscience Cholinergic Agents Biochemistry 03 medical and health sciences 0302 clinical medicine Neuroimaging Spect imaging medicine Humans Cholinergic synapse 030304 developmental biology 0303 health sciences Radiochemistry medicine.diagnostic_test business.industry Cell Biology General Medicine Pet imaging Positron emission tomography Positron-Emission Tomography Cholinergic system Cholinergic Molecular imaging Radiopharmaceuticals business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | ACS chemical neuroscience. 12(9) |
| ISSN: | 1948-7193 |
| Popis: | Since the earliest days of nuclear medicine, there has been interest in using PET and SPECT imaging to interrogate and quantify the cholinergic system. In this Viewpoint we highlight key milestones in the development of cholinergic imaging agents, including identification of radiopharmaceuticals targeting the receptors, transporters, and enzymes of the cholinergic synapse, as well as fundamental developments in the radiopharmaceutical sciences (e.g., cyclotron targetry, radiochemistry) that have enabled translation of the most promising agents into clinical use. We also provide an overview of the current state-of-the-art in cholinergic PET imaging, with an emphasis on radiotracers that are in human studies at PET centers around the world. |
| Databáze: | OpenAIRE |
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