Impact of green tea on the deleterious cardiometabolic effects of 7‐days unhealthy lifestyle in young healthy males
| Autor: | Nicola D. Hopkins, Sophie M. Holder, Richard Draijer, Kirsty A. Roberts, David A. Low, Sophie E. Carter, Dick H. J. Thijssen, Young de Graaf |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Physiology medicine.medical_treatment Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] 030204 cardiovascular system & hematology Placebo Catechin lcsh:Physiology RC1200 Young Adult 03 medical and health sciences QH301 0302 clinical medicine Double-Blind Method cardiovascular disease overfeeding RA0421 Physiology (medical) Internal medicine medicine Humans Insulin Life Style Nutrition Meal Tea lcsh:QP1-981 business.industry Original Articles Middle Aged Postprandial Period Green tea Crossover study QP Postprandial Endocrinology Cardiovascular Diseases flavonoids physical inactivity Original Article Vascular function business 030217 neurology & neurosurgery Homeostasis cardiometabolic health |
| Zdroj: | Physiological Reports, 9, 5 Physiological Reports, Vol 9, Iss 5, Pp n/a-n/a (2021) Physiological Reports Physiological Reports, 9 |
| ISSN: | 2051-817X |
| Popis: | Purpose The aim of this study was to examine if catechin‐rich green tea abrogates the negative effects of 7‐days of physical inactivity and excessive calorie‐intake on insulin homeostasis and peripheral vascular function. Methods Using a randomized, double‐blind, crossover design, twelve healthy men (29 ± 6 yrs) underwent 7‐days unhealthy lifestyle (UL), including physical inactivity (−50% steps/day) and overfeeding (+50% kcal/day). This was combined with green tea consumption (UL‐tea; 3 doses/day) or placebo (UL‐placebo). Before and after each intervention, we examined postprandial blood glucose and insulin (3‐h after a 1,202 kcal meal) and upper and lower limb vascular function (flow‐mediated dilation (FMD%)) and carotid artery reactivity (CAR%). Results UL‐placebo increased postprandial glucose and insulin, while UL‐tea decreased postprandial glucose and insulin (Time*Intervention interaction effects: both p 0.05) for brachial FMD%. Conclusion Seven days of physical inactivity and overfeeding impair insulin homeostasis and vascular function. These effects were mitigated by a daily intake of catechin‐rich green tea. The aim of this study was to examine if catechin‐rich green tea abrogates the negative effects of short‐term physical inactivity and excessive calorie‐intake on insulin homeostasis and peripheral vascular function. Twelve healthy men (29 ± 6 yrs) underwent 7‐days unhealthy lifestyle (UL), including physical inactivity (−50% steps/day) and overfeeding (+50% kcal/day) combined with green tea consumption (UL‐tea; 3 doses/day) or placebo (UL‐placebo). UL‐placebo increased post‐prandial glucose and insulin, while UL‐tea decreased post‐prandial glucose and insulin. UL‐placebo decreased carotid artery reactivity and lower limb vascular function, while UL‐tea prevented these effects. Seven days of physical inactivity‐ and overfeeding‐induced impairments in insulin homeostasis and vascular function were mitigated by daily intake of catechin‐rich green tea. |
| Databáze: | OpenAIRE |
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