ChemBank: a small-molecule screening and cheminformatics resource database
| Autor: | Paul Ferraiolo, Martin Serrano, Kathleen Petri Seiler, Paul A. Clemons, Jeremy L. Muhlich, Mary Pat Happ, Stephanie Norton, Gregory George, John P Sullivan, Nicole E. Bodycombe, Stuart L. Schreiber, Hyman A. Carrinski, Steve Brudz, Nicola Tolliday |
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| Rok vydání: | 2007 |
| Předmět: |
Chemical Phenomena
Databases Factual Drug Evaluation Preclinical Biology computer.software_genre 01 natural sciences Cell Line 03 medical and health sciences User-Computer Interface Resource (project management) Research community Genetics Computer Graphics 030304 developmental biology Life Scientists 0303 health sciences Internet Database business.industry Computational Biology Articles 0104 chemical sciences 3. Good health Metadata 010404 medicinal & biomolecular chemistry Chemistry Pharmaceutical Preparations Cheminformatics Informatics The Internet Biological Assay Analysis tools business computer Software |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 |
| Popis: | ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment includes freely available data derived from small molecules and small-molecule screens and resources for studying these data. ChemBank is unique among small-molecule databases in its dedication to the storage of raw screening data, its rigorous definition of screening experiments in terms of statistical hypothesis testing, and its metadata-based organization of screening experiments into projects involving collections of related assays. ChemBank stores an increasingly varied set of measurements derived from cells and other biological assay systems treated with small molecules. Analysis tools are available and are continuously being developed that allow the relationships between small molecules, cell measurements, and cell states to be studied. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the Broad Institute by collaborators from the worldwide research community. The goal of ChemBank is to provide life scientists unfettered access to biomedically relevant data and tools heretofore available primarily in the private sector. |
| Databáze: | OpenAIRE |
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