Effects of topically applied heterologous serum on reepithelialization rate of superficial chronic corneal epithelial defects in dogs
| Autor: | David J. Maggs, Steven R. Hollingsworth, Patricia J. Smith, J. Seth Eaton, Michael H. Brown, Bradford J. Holmberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Atropine
Male Serum medicine.medical_specialty Radial 040301 veterinary sciences medicine.medical_treatment Heterologous Muscarinic Antagonists Corneal Diseases 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Keratotomy Dogs 0302 clinical medicine Drug Therapy Double-Blind Method Tobramycin Animals Medicine Clinical significance Veterinary Sciences Dog Diseases Fluorescein Keratotomy Radial Wound Healing Debridement General Veterinary business.industry Standard treatment 04 agricultural and veterinary sciences Anti-Bacterial Agents Surgery Clinical trial Treatment Outcome chemistry Anesthesia Combination 030221 ophthalmology & optometry Drug Therapy Combination Female Ophthalmic Solutions business medicine.drug |
| Zdroj: | Eaton, JS; Hollingsworth, SR; Holmberg, BJ; Brown, MH; Smith, PJ; & Maggs, DJ. (2017). Effects of topically applied heterologous serum on reepithelialization rate of superficial chronic corneal epithelial defects in dogs. Journal of the American Veterinary Medical Association, 250(9), 1014-1022. doi: 10.2460/javma.250.9.1014. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5d27j949 Journal of the American Veterinary Medical Association, vol 250, iss 9 |
| DOI: | 10.2460/javma.250.9.1014. |
| Popis: | OBJECTIVE To assess the effects of topical application of undiluted heterologous serum on time to corneal reepithelialization in dogs with superficial chronic corneal epithelial defects (SCCEDs). DESIGN Multicenter, randomized, double-masked, controlled clinical trial. ANIMALS 41 client-owned dogs. PROCEDURES After collection of baseline clinical and historical data, dogs were randomly assigned to receive topically applied undiluted heterologous serum (n = 22) or isotonic saline (0.9% NaCl) solution (19) along with tobramycin and atropine. Epithelial debridement (at all visits) and grid keratotomy (at visits 2, 3, and 4) of SCCEDs were performed. Ophthalmic examination including fluorescein application was performed once weekly for 4 weeks or until corneal reepithelialization. Clinicians and owners were masked to treatment group. RESULTS No differences in baseline data were detected between treatment groups. No difficulties with medication administration, noncompliance, or adverse reactions were noted. All SCCEDs in both groups healed by 4 weeks after treatment began. Median time to reepithelialization (2 weeks) was not significantly different between serum-treated and placebo-treated eyes. Irrespective of treatment group, median time to reepithelialization was not significantly different for Boxers versus non-Boxer breeds. Direct correlations were detected between time to reepithelialization and vascularization score at study entry, vascularization score at time of reepithelialization, and ulcer area at study entry in both groups. Time to reepithelialization was not correlated with age, sex, or duration of signs in either group. CONCLUSIONS AND CLINICAL RELEVANCE Topical application of undiluted heterologous serum was well tolerated by dogs with SCCEDs but, as an adjunct to standard treatment, did not reduce time to corneal reepithelialization. |
| Databáze: | OpenAIRE |
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