Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging

Autor:	Guo-Rong Chen, Hai-Hao Han, Xiao-Peng He, Yi Zang, Lei Dong, Meng-Qi Fu, Lifang Liu, Sébastien Vidal, Jia Li
Přispěvatelé:	Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)
Rok vydání:	2020
Předmět:	Supramolecular chemistry 010402 general chemistry 01 natural sciences Catalysis Supramolecular assembly chemistry.chemical_compound Peroxynitrous Acid Stilbenes [CHIM]Chemical Sciences ComputingMilieux_MISCELLANEOUS Fluorescent Dyes Pyrans Quenching (fluorescence) 010405 organic chemistry Organic Chemistry Optical Imaging General Chemistry Tetraphenylethylene Combinatorial chemistry Fluorescence 0104 chemical sciences chemistry Pyran Self-assembly Glycoconjugates Peroxynitrite
Zdroj:	Chemistry-A European Journal Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (63), pp.14445-14452. ⟨10.1002/chem.202002772⟩
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.202002772⟩
Popis:	Two red-emitting dicyanomethylene-4H-pyran (DM) based fluorescent probes were designed and used for peroxynitrite (ONOO- ) detection. Nevertheless, the aggregation-caused quenching effect diminished the fluorescence and restricted their further applications. To overcome this problem, tetraphenylethylene (TPE) based glycoclusters were used to self-assemble with these DM probes to obtain supramolecular water-soluble glyco-dots. This self-assembly strategy enhanced the fluorescence intensity, leading to an enhanced selectivity and activity of the resulting glyco-dot comparing to DM probes alone in PBS buffer. The glyco-dots also exhibited better results during fluorescence sensing of intracellular ONOO- than the probes alone, thereby offering scope for the development of other similar supramolecular glyco-systems for chemical biological studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaadac0d7b33949818ae818108ca3527 https://pubmed.ncbi.nlm.nih.gov/32864796 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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