Physicochemical Properties of Amphotericin B Liposomes Prepared by Reverse-Phase Evaporation Method
| Autor: | Narong Sarisuta, Pleumchitt Rojanapanthu, Krisana Kraisintu, Korakot Chaturon |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Antifungal Agents
Chemical Phenomena Drug Compounding Sonication Pharmaceutical Science Dosage form chemistry.chemical_compound Amphotericin B Phosphatidylcholine Drug Discovery medicine Particle Size Pharmacology Liposome Chromatography Chemistry Physical Organic Chemistry Water Microscopy Electron Cholesterol chemistry Liposomes Microscopy Electron Scanning Phosphatidylcholines Particle size Diethyl ether Drug carrier medicine.drug |
| Zdroj: | Drug Development and Industrial Pharmacy. 29:31-37 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1081/ddc-120016681 |
| Popis: | The physicochemical properties of phosphatidylcholine-cholesterol liposomes containing amphotericin B and prepared by reverse-phase evaporation method were studied. Uniformly dispersed liposomal suspensions were obtained by employing 3:1 ratio (by volume) of diethyl ether to normal saline, 5 min sonication time at 7 degrees C, and evaporation of diethyl ether at 25 degrees C. Microscopic examination showed that the prepared liposomes were spheroids with unilamellar, oligolamellar, or multilamellar structure. The liposomes containing amphotericin B 2.0 mol% of total lipid led to the highest percentage of drug entrapment. Liposomes with maximum entrapment efficiency were obtained from using 250 micromol of total lipid. The liposomal amphotericin B possessing the highest drug entrapment efficiency (approximately 95%) with particle size range of 1307-1451 nm was the one composed of 1:1 molar ratio of phosphatidylcholine to cholesterol. |
| Databáze: | OpenAIRE |
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