Comparison of metabolic and neuropathy profiles of rats with streptozotocin-induced overt and moderate insulinopenia
| Autor: | Jing Wang, Dmitry Romanovsky, Joseph R. Stimers, Maxim Dobretsov, Elie D. Al-Chaer |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Diabetic neuropathy endocrine system diseases medicine.medical_treatment Streptozocin Article Rats Sprague-Dawley Random Allocation Insulin resistance Diabetic Neuropathies Metabolic Diseases Diabetes mellitus Internal medicine medicine Animals Insulin Pancreatic hormone Pain Measurement business.industry General Neuroscience nutritional and metabolic diseases medicine.disease Streptozotocin Rats Endocrinology Hyperglycemia Hyperalgesia Insulin Resistance medicine.symptom business Dyslipidemia medicine.drug |
| Zdroj: | Neuroscience. 170:337-347 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2010.06.059 |
| Popis: | To assess the relative roles of insulinopenia, hyperglycemia and dyslipidemia in pathogenesis of diabetic neuropathy, we compared plasma insulin, glucose and lipid metabolism and peripheral nerve function in rats with streptozotocin (STZ) – induced overt and moderate insulinopenia (hyperglycemic, STZ-HG; random glucose > 11 mM and normoglycemic, STZ-NG rats). While being slightly insulinopenic, STZ-NG rats are metabolically not different from control, naïve animals, by having normal glucose tolerance and normal levels of plasma glucose, glycated HbA1c, cholesterol and triglycerides. Two weeks following injection of STZ, STZ-HG but not STZ-NG rats had suppressed motor nerve conduction velocity, F-wave prevalence, withdrawal responses to heat and von Frey filament stimuli. In apparent correlation with plasma insulin level, both STZ-HG and –NG rats manifested exaggerated responses in paw pressure and colorectal distension tests. These data suggest that insulinopenia may play a leading role in the diabetic impairment of deep muscle and visceral afferent pathways while hyperglycemia/dyslipidemia may represent a key requirement for the onset and progression of electrophysiological nerve impairment and loss of superficial heat and tactile perception. STZ-NG rats offer a convenient model for the investigation of the short-term effects of insulinopenia on peripheral nerve function. |
| Databáze: | OpenAIRE |
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