LFP clustering in cortex reveals a taxonomy of Up states and near-millisecond, ordered phase-locking in cortical neurons
| Autor: | Nicholas V. Swindale, Timothy H. Murphy, Catalin Mitelut, Martin A. Spacek, Allen W. Chan |
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| Rok vydání: | 2019 |
| Předmět: |
Physiology
Action Potentials Local field potential Phase locking Brief periods 03 medical and health sciences Mice 0302 clinical medicine Animals Cluster analysis 030304 developmental biology Physics Cerebral Cortex Neurons 0303 health sciences Millisecond General Neuroscience digestive oral and skin physiology Cortical neurons Rats Mice Inbred C57BL nervous system Cortical Excitability Cats Sleep Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | J Neurophysiol |
| ISSN: | 1522-1598 |
| Popis: | During slow-wave sleep and anesthesia, mammalian cortex exhibits a synchronized state during which neurons shift from a largely nonfiring to a firing state, known as an Up-state transition. Up-state transitions may constitute the default activity pattern of the entire cortex (Neske GT. Front Neural Circuits 9: 88, 2016) and could be critical to understanding cortical function, yet the genesis of such transitions and their interaction with single neurons is not well understood. It was recently shown that neurons firing at rates >2 Hz fire spikes in a stereotyped order during Up-state transitions (Luczak A, McNaughton BL, Harris KD. Nat Rev Neurosci 16: 745–755, 2015), yet it is still unknown if Up states are homogeneous and whether spiking order is present in neurons with rates NEW & NOTEWORTHY During cortical Up-state transitions in sleep and anesthesia, neurons undergo brief periods of increased firing in an order similar to that occurring in awake states. We show that these transitions can be classified into distinct types based on the shape of the local field potential. Transition times can be defined to |
| Databáze: | OpenAIRE |
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