Five-year overall survival following chemoradiation therapy for locally advanced cervical carcinoma in women living with and without HIV infection in Botswana
| Autor: | Jessica M. George, Nicola M. Zetola, Emily MacDuffie, Surbhi Grover, Dawn Balang, Lilie L. Lin, Memory Bvochora-Nsingo, Allison Chambers, Shawna Tuli, Sebathu Chiyapo, Doreen Ramogola-Masire |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Multivariate analysis Epidemiology Population Short Report Infectious and parasitic diseases RC109-216 Low resource setting 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Survival outcomes 030212 general & internal medicine education RC254-282 Cervical cancer education.field_of_study Botswana Sub-Saharan Africa business.industry Hazard ratio HIV Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Infectious Diseases Oncology Chemoradiation 030220 oncology & carcinogenesis Tropical medicine Cohort Observational study business Cohort study |
| Zdroj: | Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-5 (2021) Infectious Agents and Cancer |
| ISSN: | 1750-9378 |
| Popis: | Purpose To compare updated prospective 5-year survival outcomes of cervical cancer patients living with and without human immunodeficiency virus (HIV) infection who initiated curative chemoradiation therapy (CRT) in a resource-limited setting. Methods & Materials Women in Botswana with locally advanced cervical cancer were enrolled in a prospective, observational, cohort study from July 2013 through January 2015. Survival outcomes were analyzed after 5 years of follow-up. Results This cohort included 143 women initiating curative CRT. Sixty-seven percent (n = 96) of cohort were women living with HIV (WLWH), all of whom were receiving antiretroviral therapy (ART) at the time of treatment initiation and boasted a median CD4 count of 481 cells/μL (IQR, 351-579 μL). The 5-year overall survival (OS) rates were 56.8% (95% CI, 40.0–70.5%) for patients without HIV infection and 55.1% (95% CI, 44.2–64.7%) for WLWH (p = 0.732). Factors associated with superior 5-year OS on multivariate analyses included baseline hemoglobin > 10 g/dL (hazard ratio (HR) 0.90, 95% CI, 0.83–0.98, p = 0.015), lower stage at diagnosis (stage I and II vs. III and IV) (HR 1.39, 95% CI 1.09–1.76, p = 0.007), and higher EQD2 (HR 0.98, 95% CI 0.97–0.99, p = 0.001). Conclusions Five-year OS was not impacted by HIV status in this population of WLWH with well-managed infection who initiated curative treatment for cervical cancer in Botswana. Regardless of HIV status, hemoglobin levels and stage at diagnosis were associated with survival. These findings suggest that treatment for cervical cancer in WLWH with well-controlled infection need not be altered solely due to HIV status. |
| Databáze: | OpenAIRE |
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