Relationship between soluble urokinase-type plasminogen activator receptor and serum biomarkers of endothelial activation in patients with idiopathic nephrotic syndrome
| Autor: | Cristina Martínez, Marina Munoz, Maria Luisa Martin, Elias Jatem, Maria Molina, Neus Roca, Alfons Segarra |
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| Přispěvatelé: | Institut Català de la Salut, [Roca N] Servicio de Nefrología Pediátrica, Consorci Hospitalari de Vic, Barcelona, Spain. Universitat de Vic, Barcelona, Spain. [Jatem E, Martín ML, Molina M, Martínez C] Servicio de Nefrología, Hospital Universitario Arnau de Vilanova, Lleida, Spain. Vascular & Renal Translational Research Group, IRBLleida, Spanish Research Network for Renal Diseases (RedInRen.ISCIII), Lleida, Spain. [Muñoz M] Servei de Nefrologia Pediàtrica, Vall d'Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Amino Acids
Peptides and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::GPI-Linked Proteins::Receptors Urokinase Plasminogen Activator [CHEMICALS AND DRUGS] medicine.medical_specialty Endothelium enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::nefrosis::síndrome nefrótico [ENFERMEDADES] endothelial activation 030204 cardiovascular system & hematology Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Nephrosis::Nephrotic Syndrome [DISEASES] Gastroenterology suPAR Endothelial activation 03 medical and health sciences 0302 clinical medicine Focal segmental glomerulosclerosis Membranous nephropathy Internal medicine Medicine Minimal change disease Endothelial dysfunction AcademicSubjects/MED00340 030304 developmental biology 0303 health sciences Transplantation nephrotic syndrome business.industry biomarkers Original Articles Ronyons - Malalties Activadors plasminògens medicine.disease aminoácidos péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::proteínas ligadas a GPI::receptores del activador del plasminógeno de tipo urocinasa [COMPUESTOS QUÍMICOS Y DROGAS] medicine.anatomical_structure SuPAR Nephrology business Nephrotic syndrome |
| Zdroj: | Scientia Clinical Kidney Journal |
| Popis: | Background Serum levels of soluble urokinase-type plasminogen activator receptor (suPAR) are high in some patients with idiopathic nephrotic syndrome (INS). Given that suPAR constitutes a predictor of vascular disease and has been associated with endothelial dysfunction, we hypothesized that suPAR levels are related to endothelial activation or dysfunction in INS patients. The aims of this study were to evaluate the relationship between serum concentrations of endothelial biomarkers and suPAR in patients with different histological patterns of INS and healthy controls, and to determine the demographic, clinical and biochemical characteristics of INS patients that influence suPAR serum levels. Methods This observational, cross-sectional study included patients with INS, diagnosed with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) or membranous nephropathy (MN) by renal biopsy. Patient demographic, clinical and biochemical characteristics were recorded and blood samples were obtained at the time of diagnosis. Measurements of suPAR and endothelial molecules via serum levels were performed using Enzyme-Linked ImmunoSorbent Assay kits. Results Patients with nephrotic syndrome (n = 152) caused by FSGS, MCD or MN had increased circulating levels of endothelial markers. suPAR levels positively correlated with age and the serum levels of almost all endothelial markers. Generally, endothelial cell molecules positively correlated with each other. suPAR levels were not associated with the histopathological pattern of INS. Conclusions In patients with INS secondary to FSGS, MCD and NM, circulating levels of suPAR are independent of the primary renal disease, and significantly associated with age, glomerular filtration rate and the levels of various endothelial markers. |
| Databáze: | OpenAIRE |
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