Effects of multisite anodal transcranial direct current stimulation combined with cognitive stimulation in patients with Alzheimer's disease and its neurophysiological correlates: A double-blind randomized clinical trial

Autor: Suellen Marinho Andrade, Daniel Gomes da Silva Machado, Leandro da Silva-Sauerc, Cláudio Teixeira Regis, Cristina Katya Torres Teixeira Mendes, Juliana Sousa Soares de Araújo, Kleyber Dantas Torres de Araújo, Larissa Pereira Costa, Maria Eduarda Bezerra Sales Queiroz, Márcio Martins Leitão, Bernardino Fernández-Calvo
Rok vydání: 2022
Předmět:
Zdroj: Neurophysiologie Clinique. 52:117-127
ISSN: 0987-7053
DOI: 10.1016/j.neucli.2022.02.003
Popis: We aimed to examine the effects of multisite anodal transcranial direct current stimulation (tDCS) combined with cognitive stimulation (CS) over 2 months on cognitive performance and brain activity, and the relationship between them, in patients with Alzheimer's disease (AD).Patients with AD were randomly assigned to an active tDCS+CS (n=18) or a sham tDCS+CS (n=18) group. Cognitive performance was assessed using the Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-cog) and brain activity using EEG (spectral power and coherence analysis) before and after the intervention. Multisite anodal tDCS (2 mA, 30 min) was applied over six brain regions [left and right dorsolateral prefrontal cortex (F3 and F4), Broca's area (F5), Wernicke's area (CP5), left and right somatosensory association cortex (P3 and P4)] for 24 sessions (three times a week). Both groups performed CS during tDCS.Anodal tDCS+CS delays cognitive decline (ADAS-cog change) to a greater extent than sham tDCS+CS (-3.4±1.1 vs. -1.7±0.4; p=.03). Bilateral EEG coherence at high and low frequencies was greater for the active tDCS+CS than sham+CS group for most electrode pairs assessed (p .05). The post-intervention ADAS-cog change score was predictive for EEG coherence at different sites (R²=.59 to .68; p .05) in the active but not in the sham tDCS+CS group.Anodal tDCS+CS improved overall cognitive function and changed EEG brain activity compared to sham tDCS+CS. Changes in cognitive performance were associated with changes in EEG measures of brain activity. Anodal tDCS+CS appears to be a promising therapeutic strategy to modulate cortical activity and improve cognitive function in patients with AD.
Databáze: OpenAIRE
Externí odkaz: