Factors associated with the development of persistently depressed cardiac output during the first year after cardiac transplantation
| Autor: | Y. Khatib, W. G. Kao, Ching-Tung Lung, Maria Rosa Costanzo, M. R. Johnson, J. J. Glazier, A. I. Heroux, G. M. Mullen, S. G. Fisher, D. Koch |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output medicine.medical_treatment Cardiac Output Low Cardiac index Hemodynamics Postoperative Complications Internal medicine medicine Humans Survivors Retrospective Studies Heart transplantation Analysis of Variance business.industry Retrospective cohort study General Medicine Perioperative Middle Aged Prognosis Transplantation Cardiology Heart Transplantation Female Cardiology and Cardiovascular Medicine business Complication Follow-Up Studies |
| Zdroj: | Clinical Cardiology. 17:489-494 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.4960170906 |
| Popis: | The purpose of this study was to determine factors associated with the development of a persistently depressed cardiac output during the first year after cardiac transplantation. With this aim in mind, the records of 133 consecutive patients undergoing orthotopic cardiac transplantation and surviving foror = 1 year after transplantation were reviewed. For each patient, the mean cardiac index for each of the 3-month periods, 0-3, 4-6, 7-9, and 10-12 months after transplantation was calculated. Of the 133 patients, 19 (14%) had a mean cardiac index2.4 l/min/m2 duringor = 3 of these 3-month periods. The pre- and post-transplantation clinical, immunologic, and hemodynamic data of these 19 patients (study group) were compared with the remaining 114 patients (control group). Compared with the control group, the patients in the study group were older (56 +/- 5 vs. 46 +/- 15 years; p = 0.0001), more frequently had ischemic heart disease as the original diagnosis (58 vs. 37%; p0.05), had a lower preoperative cardiac index (1.91 +/- 0.53 vs. 2.71 +/- 1.0 l/min/m2; p = 0.0001), more frequently did not receive perioperative anti-T cell therapy (47 vs. 25%; p = 0.046), and had a greater median number of infections during the first year after transplantation (5 vs. 3; p = 0.027). However, only one factor--a low preoperative cardiac index--emerged as an independent predictor of the development of a persistently depressed cardiac index during the first year after transplantation.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|