Influence of Aortic Impedance on the Development of Pressure-Overload Left Ventricular Hypertrophy in Rats
| Autor: | Yuji Hisamatsu, Tomoko Ohkusa, Tsutomu Ryoke, Masafumi Yano, Masakazu Obayashi, Masunori Matsuzaki, Shigeki Kobayashi, Katsutoshi Yamakawa, Michihiro Kohno |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Hemodynamics Aorta Thoracic Blood Pressure Left ventricular hypertrophy Aortic Coarctation Muscle hypertrophy Afterload Heart Rate Reference Values Physiology (medical) medicine.artery Internal medicine medicine Animals Aorta Abdominal Rats Wistar Aldosterone Pressure overload Aorta business.industry Angiotensin II Myocardium Abdominal aorta Heart medicine.disease Rats Blood pressure Cardiology Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 94:3362-3368 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background Aortic input impedance, which represents LV afterload, is considered to be a major determinant for the development of pressure-overload left ventricular (LV) hypertrophy. Methods and Results To test whether the sustained change in aortic input impedance might affect the mode of development of LV hypertrophy, coarctation of either the ascending aorta (G1, n=13) or suprarenal abdominal aorta (G2, n=12) was performed over 4 weeks in 6-week-old Wistar rats. Although peak LV pressure and total systemic resistance were increased similarly in G1 and G2, time to peak LV pressure was decreased by 24% ( P P P Conclusions The sustained early systolic loading due to the increase in characteristic impedance was accompanied by less concentric, reduced hypertrophy, whereas the sustained late systolic loading due to the augmented arterial wave reflection was accompanied by concentric, adequate hypertrophy. |
| Databáze: | OpenAIRE |
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