| Popis: |
This investigation was undertaken to determine the freely available sulfhydryl (S-H) content of normal human sera, the conditions for collection of the blood samples and the effect of S-H group reactants on sera. These group reactants are frequently used as dermatologie therapeutic agents. Arsenic is one of the drugs which is used systemically and which is thought to be a S-H group reactant. X-radiation and ultraviolet light as used in dermatologie therapy may also act by oxidizing S-H groups in the skin. In most instances, these agents may convert S-H groups to S-S linkages by oxidation according to the following equation: 2R-S-H + (O) -> R-S-S-R + HOH Serum was used to evaluate the S-H groups, because some of these agents are used parenterally. It was also our impression prior to these studies, that the action on serum S-H groups may parallel the effect on skin S-H groups. |
