Magnetically actuated microstructured surfaces can actively modify cell migration behaviour
| Autor: | F. Khademolhosseini, Mu Chiao, Chinten James Lim, Chi-Chao Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Materials science Tissue Engineering Surface Properties Cell Culture Techniques Biomedical Engineering Cell migration Nanotechnology 02 engineering and technology Cell movement 021001 nanoscience & nanotechnology 03 medical and health sciences Magnetic Fields 030104 developmental biology Tissue engineering Cell Movement Human Umbilical Vein Endothelial Cells Humans 0210 nano-technology Molecular Biology |
| Zdroj: | Biomedical Microdevices. 18 |
| ISSN: | 1572-8781 1387-2176 |
| DOI: | 10.1007/s10544-016-0033-7 |
| Popis: | We present a study on the application of magnetically actuated polymer micropillar surfaces in modifying the migration behaviour of cells. We show that micropillar surfaces actuated at a frequency of 1 Hz can cause more than a 5-fold decrease in cell migration rates compared to controls, whereas non-actuated micropillar surfaces cause no statistically significant alterations in cell migration rates. The effectiveness of the micropillar arrays in impeding cell migration depends on micropillar density and placement patterns, as well as the direction of micropillar actuation with respect to the direction of cell migration. Since the magnetic micropillar surfaces presented can be actuated remotely with small external magnetic fields, their integration with implants could provide new possibilities for in-vivo tissue engineering applications. |
| Databáze: | OpenAIRE |
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